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Curcumin#458-37-7

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Chemical Name：Curcumin

CAS No.:458-37-7

Molecular Formula：C21H20O6

Sample: Available

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Product Details

Curcumin#458-37-7

Curcumin is usually an orange-yellow crystalline powder. At room temperature, it appears bright yellow with a slight earthy smell and is odorless. At normal pressure, the boiling point is approximately 418.73°C (rough estimate). Some data also show that at a pressure of 760mmHg, the boiling point is 591.4°C. Slightly soluble in water and slightly soluble in hot water; It is readily soluble in glacial acetic acid and soluble in organic solvents such as ethanol, acetone, ether and dichloromethane.

Curcumin#458-37-7

Curcumin Chemical Properties

Melting point	183 °C
Boiling point	418.73°C (rough estimate)
density	0.93
vapor density	13 (vs air)
refractive index	1.4155-1.4175
Fp	208.9±23.6 °C
storage temp.	2-8°C
solubility	ethanol: 10 mg/mL
form	powder
Colour Index	75300
pka	8.09(at 25℃)
color	orange
PH Range	Yellow (7.8) to red-brown (9.2)
Odor	Odorless
biological source	Curcuma longa (Turmeric)
Water Solubility	Slightly soluble (hot)
λmax	430nm
Merck	14,2673
Solvent	Ethanol
Concentration	1 mCi/ml
Specific Activity	5-15 Ci/mmol
BRN	2306965
Stability:	Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
Major Application	Cosmetics, drug-eluting stents, inhibition of formation of skin-wrinkles, treating alzheimer’s disease, skin diseases, coronary restenosis, diabetes, obesity, leukemia, neurofibromas, cancer, antimicrobial, antiviral, antiinflammatory, antiprostate cancer
InChIKey	VFLDPWHFBUODDF-FCXRPNKRSA-N
LogP	3.290 (est)
CAS DataBase Reference	458-37-7(CAS DataBase Reference)
EPA Substance Registry System	Curcumin (458-37-7)

Product Usage

A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.

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