N-Methyl-2-Pyrrolidone CAS# 872-50-4
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Chemical Name:N-Methyl-2-Pyrrolidone
CAS No.: 872-50-4
Molecular Formula:C5H9NO
Molecular weight:99.13
Sample: Available
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N-Methyl-2-Pyrrolidone CAS# 872-50-4
N-Methyl-2-pyrrolidone is a colourless or light yellow liquid with an amine odour. It can undergo a number of chemical reactions even though it is accepted as a stable solvent. It is resistant to hydrolysis under neutral conditions, but strong acid or base treatment results in ring opening to 4-methyl aminobutyric acid. N-Methyl-2-pyrrolidone can be reduced to 1-methyl pyrrolidine with borohydride. Treatment with chlorinating agents results in amide formation,an intermediate which can undergo further substitution, while treatment with amyl nitrate yields the nitrate. Olefins can be added to the 3 position by treatment first with oxalic esters, then with appropriate aldehyes (Hort and Anderson 1982).
N-Methyl-2-pyrrolidone Chemical Properties |
Melting point | -24 °C (lit.) |
Boiling point | 202 °C (lit.) 81-82 °C/10 mmHg (lit.) |
density | 1.028 g/mL at 25 °C (lit.) |
vapor density | 3.4 (vs air) |
vapor pressure | 0.29 mm Hg ( 20 °C) |
refractive index | n |
Fp | 187 °F |
storage temp. | Store at +5°C to +30°C. |
solubility | ethanol: miscible0.1ML/mL, clear, colorless (10%, v/v) |
form | Liquid |
pka | -0.41±0.20(Predicted) |
color | ≤20(APHA) |
PH | 8.5-10.0 (100g/l, H2O, 20℃) |
Odor | Slight amine odor |
PH Range | 7.7 - 8.0 |
explosive limit | 1.3-9.5%(V) |
Water Solubility | >=10 g/100 mL at 20 ºC |
Sensitive | Hygroscopic |
λmax | 283nm(MeOH)(lit.) |
Merck | 14,6117 |
BRN | 106420 |
Dielectric constant | 32.200000000000003 |
Stability: | Stable, but decomposes upon exposure to light. Combustible. Incompatible with strong oxidizing agents, strong acids, reducing agents, bases. |
InChIKey | SECXISVLQFMRJM-UHFFFAOYSA-N |
LogP | -0.46 at 25℃ |
Surface tension | 41.3mN/m at 293.15K |
CAS DataBase Reference | 872-50-4(CAS DataBase Reference) |
NIST Chemistry Reference | 2-Pyrrolidinone, 1-methyl-(872-50-4) |
EPA Substance Registry System | N-Methyl-2-pyrrolidone (872-50-4) |
Safety Information |
Hazard Codes | T,Xi |
Risk Statements | 45-65-36/38-36/37/38-61-10-46 |
Safety Statements | 41-45-53-62-26 |
WGK Germany | 1 |
RTECS | UY5790000 |
F | 3-8-10 |
Autoignition Temperature | 518 °F |
TSCA | Y |
HS Code | 2933199090 |
Hazardous Substances Data | 872-50-4(Hazardous Substances Data) |
Toxicity | LD50 orally in Rabbit: 3598 mg/kg LD50 dermal Rabbit 8000 mg/kg |
Product Usage
N-Methyl-2-pyrrolidone is a polar solvent that is used in organic chemistry and polymer chemistry. Large scale applications include the recovery and purification of acetylenes, olefins, and diolefins, gas purification, and aromatics extraction from feedstocks. N-Methyl-2-pyrrolidone is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts.
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