N-Methyl-2-Pyrrolidone CAS# 872-50-4

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Chemical Name:N-Methyl-2-Pyrrolidone

CAS No.: 872-50-4

Molecular Formula:C5H9NO

Molecular weight:99.13

Sample: Available

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Product Details

N-Methyl-2-Pyrrolidone CAS# 872-50-4

N-Methyl-2-pyrrolidone is a colourless or light yellow liquid with an amine odour. It can undergo a number of chemical reactions even though it is accepted as a stable solvent. It is resistant to hydrolysis under neutral conditions, but strong acid or base treatment results in ring opening to 4-methyl aminobutyric acid. N-Methyl-2-pyrrolidone can be reduced to 1-methyl pyrrolidine with borohydride. Treatment with chlorinating agents results in amide formation,an intermediate which can undergo further substitution, while treatment with amyl nitrate yields the nitrate. Olefins can be added to the 3 position by treatment first with oxalic esters, then with appropriate aldehyes (Hort and Anderson 1982).

N-Methyl-2-Pyrrolidone CAS# 872-50-4


N-Methyl-2-pyrrolidone Chemical Properties

Melting point 

-24 °C (lit.)

Boiling point 

202 °C (lit.) 81-82 °C/10 mmHg (lit.)

density 

1.028 g/mL at 25 °C (lit.)

vapor density 

3.4 (vs air)

vapor pressure 

0.29 mm Hg ( 20 °C)

refractive index 

n20/D 1.479

Fp 

187 °F

storage temp. 

Store at +5°C to +30°C.

solubility 

ethanol: miscible0.1ML/mL, clear, colorless (10%, v/v)

form 

Liquid

pka

-0.41±0.20(Predicted)

color 

≤20(APHA)

PH

8.5-10.0 (100g/l, H2O, 20℃)

Odor

Slight amine odor

PH Range

7.7 - 8.0

explosive limit

1.3-9.5%(V)

Water Solubility 

>=10 g/100 mL at 20 ºC

Sensitive 

Hygroscopic

λmax

283nm(MeOH)(lit.)

Merck 

14,6117

BRN 

106420

Dielectric constant

32.200000000000003

Stability:

Stable, but decomposes upon exposure to light. Combustible. Incompatible with strong oxidizing agents, strong acids, reducing agents, bases.

InChIKey

SECXISVLQFMRJM-UHFFFAOYSA-N

LogP

-0.46 at 25℃

Surface tension

41.3mN/m at 293.15K

CAS DataBase Reference

872-50-4(CAS DataBase Reference)

NIST Chemistry Reference

2-Pyrrolidinone, 1-methyl-(872-50-4)

EPA Substance Registry System

N-Methyl-2-pyrrolidone (872-50-4)


Safety Information

Hazard Codes 

T,Xi

Risk Statements 

45-65-36/38-36/37/38-61-10-46

Safety Statements 

41-45-53-62-26

WGK Germany 

1

RTECS 

UY5790000

3-8-10

Autoignition Temperature

518 °F

TSCA 

Y

HS Code 

2933199090

Hazardous Substances Data

872-50-4(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: 3598 mg/kg LD50 dermal Rabbit 8000 mg/kg

Product Usage

N-Methyl-2-pyrrolidone is a polar solvent that is used in organic chemistry and polymer chemistry.  Large scale applications include the recovery and purification of acetylenes, olefins, and diolefins, gas purification, and aromatics extraction from feedstocks. N-Methyl-2-pyrrolidone is a versatile industrial solvent.  NMP is currently approved for use only in veterinary pharmaceuticals.  The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts.


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