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Paclitaxel#33069-62-4

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Chemical Name：Paclitaxel

CAS No.:33069-62-4

Molecular Formula：C47H51NO14

Sample: Available

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Product Details

Paclitaxel#33069-62-4

Paclitaxel, a natural product isolated from the bark of the Pacific yew, is effective in treating refractory metastatic ovarian cancer. Unlike any other antineoplastic agents, paclitaxel appears to have several possible mechanisms of action, including an antimicrotubule action through the promotion of tubulin polymerization and stabilization of microtubules, thereby, halting mitosis and promoting cell death.

Paclitaxel#33069-62-4

Paclitaxel Chemical Properties

Melting point	213 °C (dec.)(lit.)
alpha	D20 -49° (methanol)
Boiling point	774.66°C (rough estimate)
density	0.200
refractive index	-49 ° (C=1, MeOH)
Fp	9℃
storage temp.	2-8°C
solubility	methanol: 50 mg/mL, clear, colorless
form	powder
pka	11.90±0.20(Predicted)
color	white
Water Solubility	0.3mg/L(37 ºC)
λmax	227nm(MeOH)(lit.)
Merck	14,6982
BRN	1420457
Stability:	Stable. Incompatible with strong oxidizing agents. Combustible.
InChIKey	RCINICONZNJXQF-MZXODVADSA-N
LogP	3.950 (est)
CAS DataBase Reference	33069-62-4(CAS DataBase Reference)
EPA Substance Registry System	Paclitaxel (33069-62-4)

Safety Information

Hazard Codes	Xn
Risk Statements	37/38-41-42/43-62-68-40-48-20/21/22-68/20/21/22
Safety Statements	22-26-36/37/39-45
RIDADR	1544
WGK Germany	3
RTECS	DA8340700
F	10-21
HazardClass	6.1(b)
PackingGroup	III
HS Code	29329990
Hazardous Substances Data	33069-62-4(Hazardous Substances Data)
Toxicity	LD50 intraperitoneal in mouse: 128mg/kg

Product Usage

Paclitaxel is an antineoplastic that used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanc ed forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It is also used in the study of structure and function of microtubles into tubulin.

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