Artemisinin#63968-64-9

Artemisinin#63968-64-9

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Chemical Name:Artemisinin

CAS No.:63968-64-9

Molecular Formula:C15H22O5

Sample: Available

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Product Details

Artemisinin#63968-64-9

Artemisinin is an antimalarial agent with anticancer activity. It is an iron(II) oxide-reactive endoperoxide that generates reactive oxygen species (ROS) upon cleavage of its endoperoxide bridge. It reduces the growth of various P. falciparum strains in vitro (IC50s = 3.98-20.36 nM) and reduces parasitemia in mice infected with P. falciparum with a curative dose (CD50) value of 140 mg/kg. It also reduces P. berghei infection in mice (ED50 = 5.6 mg/kg per day).

Artemisinin#63968-64-9



Artemisinin Chemical Properties

Melting point 

156-157 °C (lit.)

alpha 

76 º (c=0.5,MeOH)

Boiling point 

344.94°C (rough estimate)

density 

1.0984 (rough estimate)

refractive index 

75 ° (C=0.5, MeOH)

storage temp. 

-20°C

solubility 

Soluble to 100mM in DMSO and to 75mM in ethanol

form 

White to off-white crystalline solid.

color 

Needles

Optical Rotation

[α]20/D +76°, c = 0.5 in methanol

Merck 

14,817

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides. May absorb, and react with, carbon dioxide from the air.

InChI

InChI=1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1

InChIKey

BLUAFEHZUWYNDE-NNWCWBAJSA-N

SMILES

O1[C@]23[C@@]4([H])O[C@@](C)(CC[C@@]2([H])[C@H](C)CC[C@@]3([H])[C@@H](C)C(=O)O4)O1

LogP

2.900


Safety Information

Safety Statements 

22-24/25

WGK Germany 

2

RTECS 

KD4170000

HS Code 

29322985

Toxicity

LD50 in mice (mg/kg): 5105 orally; 2800 i.m.; 1558 i.p. (Koch); LD50 in mice, rats (mg/kg): 4228, 5576 orally; 3840, 2571 i.m. (China Cooperative Research Group on Qinghaosu)


Product Usage

Artemisia annua, as an antimalarial drug, contains artemisinin and its derivatives, which have remarkable effects in treating malaria (including various types such as malignant malaria, interday malaria, chloroquine-resistant malaria, and cerebral malaria, covering dangerous types). It features high efficiency, rapidity, low toxicity, and no cross-resistance with chloroquine



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